CICLO DE PALESTRAS DO CENTRO DE QUÍMICA
Research Institute for Medicines (iMed.ULisboa), Fac.Pharmacy, Univ. Lisboa,
ANFITEATRO DA ECUM
23 MAIO 2018 14:30H
The development of biorenewable chemical building blocks for chemical based commodities is an important issue. Carbohydrates are valuable resources for the generation of synthetic building blocks. Among them, glucose and xylose can be used without competing with the food sector being known their transformation to the furan functionality such as 5-(hydroxymethyl)furfural(HMF), and furfural respectively. Recently, this team explored the Ru-catalyzed hydrofurylation of alkenes, involving a directed C−H activation at C3 of the furan ring.
Here in, is presented a new functionalization of the biomass derived compounds furfural and HMF at C-3 position via catalytic C-H activation directed by temporary pendant group attached to the furan ring as imine via Ru-catalyzed hydroarylation of olefins.
The optimization of reactions conditions were performed and the reaction scope evaluated. This atom-economical strategy has potential for an array of direct applications in Ru(0)-catalyzed C−H bond arylations using removable directing groups.