SELF-i

Nome e referência do Projeto 

SELF-i – Self-reporting immunostimulating formulation for on-demand cancer therapy with realtime treatment response monitoring

Acrónimo

SELF-i

Data de início e conclusão:

02/07/2018 – 01/07/2021

Objetivos:

Cancer represents one of the biggest societal challenges of our days. Current therapies are focused on the direct depletion of the tumoural mass, but lack specificity which translates into severe damage to healthy tissues. A potential solution come with a paradigm change to, instead of use drugs to destroy cancer cells, unleash an immune response in the patient to allow him/her deal with the tumoural challenge by himself. Nanotechnology can play a crucial role in this strategy by helping deliver immunostimulating drugs to the tumor microenvironment. The main bottleneck of nanotechnology application to healthcare, the low ability to target and accumulate in selected tissues, can be overcome in this particular application thanks to the ability of the immune system to self-regulate and amplify its response after an initial trigger. In this scenario we propose the preparation and validation of a responsive formulation able to respond to internal (pH) and external (T) stimuli to locally release a cocktail of immunostimulating and chemotherapeutic drugs to fight against colorectal cancer. Furthermore, our proposed probe will be provided with a reporting system to monitor in real time the response to the treatment.

Entidade financiadora:

Programa Operacional Regional do Norte 2020/FCT – NORTE-01-0145-FEDER-028052

Montante do financiamento (global e UMinho):

Global: 239 718.22 (€)

Universidade do Minho: 75 975.00 (€)

Beneficiário Principal: INL – International Nanotechnology Laboratory

University of Minho (UM)
Susana Costa, (CQUM)
Manuela Raposo, (CQUM)

International Nanotechnology Laboratory (INL)
Juan Gallo Páramo, (PI)
Manuel Bañobre López, (Co-PI)
Lorena Garcia Hevia


Research Groups:


Latest news:
Biossensores para a monitorização de biomoléculas
Biossensores para a monitorização de biomoléculas
PALESTRA DO CENTRO DE QUÍMICA Maria Goreti Ferreira Sales Instituto Superior de Engenharia do Porto, Porto ANFITEATRO DO DEPARTAMENTO DE QUÍMICA 15 novembro 2019 10h30 Biossensores para a monitorização de biomoléculas A monitorização de...
Capa da revista Nature Reviews Chemistry
Capa da revista Nature Reviews Chemistry
The synergic effect of water and biomolecules in intracellular phase separation Artigo publicado como capa da revista Nature Reviews Chemistry (Impact Factor =30,6) Foi publicado na edição de Setembro da Revista Nature Reviews Chemistry...



2018 - Centro de Química - Universidade do Minho

Financiado por fundos nacionais através da FCT - Fundação para a Ciência e a Tecnologia,
I.P., no âmbito do Projetos Estratégicos UID/QUI/00686/2013 , UID/QUI/00686/2016 e UID/QUI/00686/2018


website credits