The Applied Biomolecular Chemistry (ABC) research group is involved in a variety of projects that are linked by the use of biomolecules as targets or as tools for novel applications. The members of this group have different scientific backgrounds but all have a common foundation in the domain of Chemistry that permits them to contribute to interdisciplinary projects. These projects are carried out in collaboration with partners from other research centres, in Portugal and abroad.
The research interests of ABC group are:
- Development of new methods and new intermediates for peptide synthesis and their application in the production of peptides, peptide analogues and peptidomimetics
- Preparation of metal complexes for medical imaging.
- Development of new supramolecular hydrogels based on low molecular weight peptides
- Preparation and purification of biomolecules for therapeutic applications.
Paula Margarida Ferreira
- ABC Group Leader: Paula Margarida Ferreira
Recent ABC Publications:
- Ga[NO2A-N-(α-amino)propionate] chelates: Synthesis and evaluation as potential tracers for<sup>68</sup>Ga PET
Ferreira, M.F.; Pereira, G.; Andr\'e, J.P.; Prata, M.I.M.; Ferreira,
Journal of the Chemical Society. Dalton Transactions, 2014
- Ln[DO3A-N-α-(pyrenebutanamido)propionate] complexes: Optimized relaxivity and NIR optical properties
Ferreira, M.F.; Pereira, G.; Martins, A.F.; Martins, C.I.O.; Prata, M.
Dalton Transactions, 2014
- Dehydrodipeptide Hydrogelators Containing Naproxen N-Capped Tryptophan: Self-Assembly, Hydrogel Characterization, and Evaluation as Potential Drug Nanocarriers
Vilaca, Helena; Hortelao, Ana C. L.; Castanheira, Elisabete M. S.; Queiroz, Maria-Joao R. P.; Hilliou&com
Biomacromolecules, 2015
- New cyclic RGD peptides: Synthesis, characterization, and theoretical activity towards α<inf>v</inf>β<inf>3</inf>integrin
Vilac?a, H.; Ferreira, P.M.T.; Micaelo, N.M.
Tetrahedron, 2014
- Toxicity and structure-activity relationship (SAR) of α,β-dehydroamino acids against human cancer cell lines
Videira, R.A.; Andrade, P.B.; Monteiro, L.S.; Valent\~ao, P.; Ferreira, P&perio
Toxicology in Vitro, 2018
- Phototriggered release of tetrapeptide AAPV from coumarinyl and pyrenyl cages
Santos, F.C.; Soares, A.M.S.; Gon?alves, M.S.T.; Costa, S.P.G&pe
Amino Acids, 2017
- Interactions between an Aryl Thioacetate-Functionalized Zn(II) Porphyrin and Graphene Oxide
Mao, Boyang; Calatayud, David G.; Mirabello, Vincenzo; Hodges, Benjamin J.; Ribeiro Martins, Jose Alberto; Botchway, Stanle
Advanced Functional Materials, 2016
- New 2,4,5-triarylimidazoles based on a phenylalanine core: synthesis, photophysical characterization and evaluation as fluorimetric chemosensors for ion recognition
Esteves, C.I.C.; Raposo, M.M.M.; Costa, S.P.G.
Dyes and Pigments, 2016
- Magnetogels: Prospects and main challenges in biomedical applications
Veloso, S.R.S.; Ferreira, P.M.T.; Martins, J.A.; Coutinho, P.J.G.&a
Pharmaceutics, 2018
- Gold nanoparticles functionalised with fast water exchanging Gd<sup>3+</sup>chelates: Linker effects on the relaxivity
Ferreira, M.F.; Gon?alves, J.; Mousavi, B.; Prata, M.I.M.; Rodrigues, S&period
Dalton Transactions, 2015
- Photoactivable heterocyclic cages in a comparative release study of butyric acid as a model drug
Piloto, A.M.; Hungerford, G.; Sutter, J.U.; Soares, A.M.S.; Costa, S.P
Journal of Photochemistry and Photobiology A: Chemistry, 2015
- Non-canonical amino acids bearing thiophene and bithiophene: synthesis by an Ugi multicomponent reaction and studies on ion recognition ability
Esteves, C.I.C.; Raposo, M.M.M.; Costa, S.P.G.
Amino Acids, 2017
- Synthesis of new benzo[a]phenoxazinium probes possessing carboxylic ester, hydroxyl and amino functional groups: Photophysical studies in dry ethanol and conjugation with CdTe quantum dots
Raju, B.R.; Garcia, A.M.F.; Costa, A.L.S.; Coutinho, P.J.G.&sem
Dyes and Pigments, 2014
- Partitioning of bovine lactoferrin in aqueous two-phase system containing poly(ethylene glycol) and sodium citrate
Costa, A.R.D.; Coimbra, J.S.D.R.; Ferreira, L.A.; Marcos, J.C.&
Food and Bioproducts Processing, 2015
- Dinuclear DOTA-based Gd<sup>III</sup> chelates - Revisiting a straightforward strategy for relaxivity improvement
Fontes, A.; Karimi, S.; Helm, L.; Yulikov, M.; Ferreira, P.M.; Andr\'e,
European Journal of Inorganic Chemistry, 2015
- Dextrin-Based Nanomagnetogel: In Vivo Biodistribution and Stability
Goncalves, C.; Silva, J. P.; Antunes, I. F.; Ferreira, M. F. M.; Martins, J&a
Bioconjugate Chemistry, 2015
- Interaction of fluorescent quinolin-2-one and coumarin derivatives including dipeptides with lipid bilayers
Abreu, A.S.; Hermenegildo, B.F.C.; Ferreira, P.M.T.; Queiroz, M.J.R&period
RSC Advances, 2016
- N-Pyrenylmethoxycarbonyl phototriggers for the release of serotonin, tryptamine and their biosynthetic precursors
Fernandes, M.J.G.; Gon?alves, M.S.T.; Costa, S.P.G.
Dyes and Pigments, 2018
- Photolytic release of bioactive carboxylic acids from fused pyran conjugates
Concei?\~ao, R.; Hungerford, G.; Costa, S.P.G.; Gon?alves, M.S.T.
Dyes and Pigments, 2018
- Aminobenzocoumarinylmethyl esters as photoactive precursors for the release of butyric acid
Soares, A.M.S.; Hungerford, G.; Costa, S.P.G.; Gonçalves, M.S.T.
New Journal of Chemistry, 2015
- Light triggering of 5-aminolevulinic acid from fused coumarin ester cages
Soares, A.M.S.; Hungerford, G.; Gon?alves, M.S.T.; Costa, S.P.G.
New Journal of Chemistry, 2017
- Synthesis of N-alkyl-C<sup>α,α</sup>-dimethylglycine derivatives
Monteiro, L.S.; Pereira-Lima, S.M.M.A.; Pereira, S.; Machado, J.N.
Arkivoc, 2014
- Synthesis and preliminary biological evaluation of new phenolic and catecholic dehydroamino acid derivatives
Monteiro, L.S.; Oliveira, S.; Paiva-Martins, F.; Ferreira, P.M.T.; Pereira, D.M&a
Tetrahedron, 2017
- Dehydrodipeptide Hydrogelators Containing Naproxen N-Capped Tryptophan: Self-Assembly, Hydrogel Characterization, and Evaluation as Potential Drug Nanocarriers
Vila?a, H.; Hortel\~ao, A.C.L.; Castanheira, E.M.S.; Queiroz, M.-J.R&a
Biomacromolecules, 2015
- Synthesis and evaluation of the chromo-fluorogenic recognition ability of imidazoquinoline derivatives toward ions
Mar\'in-Hern\'andez, C.; Santos-Figueroa, L.E.; El Sayed, S.; Pardo, T.; Raposo, M&p
Dyes and Pigments, 2015
- Fluorescent phenanthroimidazoles functionalized with heterocyclic spacers: Synthesis, optical chemosensory ability and two-photon absorption (TPA) properties
Ferreira, R.C.M.; Costa, S.P.G.; Gon?alves, H.; Belsley, M.; Raposo, M&
New Journal of Chemistry, 2017
- Grafting of adipic anhydride to carbon nanotubes through a Diels-Alder cycloaddition/oxidation cascade reaction
Ara\'ujo, R.F.; Proen?a, M.F.; Silva, C.J.; Castro, T.G.; Melle-Fran
Carbon, 2016
- Gold nanoparticles functionalised with fast water exchanging Gd3+ chelates: linker effects on the relaxivity
Ferreira, Miguel F.; Goncalves, Janaina; Mousavi, Bibimaryam; Prata, Maria I. M.; Rodrigues, Sergio P. J.&
Dalton Transactions, 2015
- Synthesis of dehydrodipeptide and N-ethyl-dehydrodipeptide derivatives with an α-aminoisobutyric acid residue
Monteiro, L.S.; Pereira-Lima, S.M.; Pereira, S.
Current Chemical Biology, 2014
- Peptaibolin analogues by incorporation of α,α-dialkylglycines: Synthesis and study of their membrane permeating ability
Castro, V.I.B.; Carvalho, C.M.; Fernandes, R.D.V.; Pereira-Lima, S.M.M&per
Tetrahedron, 2016
