The Applied Biomolecular Chemistry (ABC) research group is involved in a variety of projects that are linked by the use of biomolecules as targets or as tools for novel applications. The members of this group have different scientific backgrounds but all have a common foundation in the domain of Chemistry that permits them to contribute to interdisciplinary projects. These projects are carried out in collaboration with partners from other research centres, in Portugal and abroad.
The research interests of ABC group are:
- Development of new methods and new intermediates for peptide synthesis and their application in the production of peptides, peptide analogues and peptidomimetics
- Preparation of metal complexes for medical imaging.
- Development of new supramolecular hydrogels based on low molecular weight peptides
- Preparation and purification of biomolecules for therapeutic applications.
Paula Margarida Ferreira
- ABC Group Leader: Paula Margarida Ferreira
Recent ABC Publications:
- Magnetogels: Prospects and main challenges in biomedical applications
Veloso, S.R.S.; Ferreira, P.M.T.; Martins, J.A.; Coutinho, P.J.G.&a
Pharmaceutics, 2018
- Synthesis of N-alkyl-C<sup>α,α</sup>-dimethylglycine derivatives
Monteiro, L.S.; Pereira-Lima, S.M.M.A.; Pereira, S.; Machado, J.N.
Arkivoc, 2014
- Synthesis of new benzo[a]phenoxazinium probes possessing carboxylic ester, hydroxyl and amino functional groups: Photophysical studies in dry ethanol and conjugation with CdTe quantum dots
Raju, B.R.; Garcia, A.M.F.; Costa, A.L.S.; Coutinho, P.J.G.&sem
Dyes and Pigments, 2014
- Ln[DO3A-N-α-(pyrenebutanamido)propionate] complexes: Optimized relaxivity and NIR optical properties
Ferreira, M.F.; Pereira, G.; Martins, A.F.; Martins, C.I.O.; Prata, M.
Dalton Transactions, 2014
- New self-assembled supramolecular hydrogels based on dehydropeptides
Vila?a, H.; Pereira, G.; Castro, T.G.; Hermenegildo, B.F.; Shi, J.; Faria
Journal of Materials Chemistry B, 2015
- Dehydrodipeptide Hydrogelators Containing Naproxen N-Capped Tryptophan: Self-Assembly, Hydrogel Characterization, and Evaluation as Potential Drug Nanocarriers
Vila?a, H.; Hortel\~ao, A.C.L.; Castanheira, E.M.S.; Queiroz, M.-J.R&a
Biomacromolecules, 2015
- Synthesis and evaluation of the chromo-fluorogenic recognition ability of imidazoquinoline derivatives toward ions
Mar\'in-Hern\'andez, C.; Santos-Figueroa, L.E.; El Sayed, S.; Pardo, T.; Raposo, M&p
Dyes and Pigments, 2015
- Aminobenzocoumarinylmethyl esters as photoactive precursors for the release of butyric acid
Soares, A.M.S.; Hungerford, G.; Costa, S.P.G.; Gonçalves, M.S.T.
New Journal of Chemistry, 2015
- Dehydrodipeptide Hydrogelators Containing Naproxen N-Capped Tryptophan: Self-Assembly, Hydrogel Characterization, and Evaluation as Potential Drug Nanocarriers
Vilaca, Helena; Hortelao, Ana C. L.; Castanheira, Elisabete M. S.; Queiroz, Maria-Joao R. P.; Hilliou&com
Biomacromolecules, 2015
- Light triggering of 5-aminolevulinic acid from fused coumarin ester cages
Soares, A.M.S.; Hungerford, G.; Gon?alves, M.S.T.; Costa, S.P.G.
New Journal of Chemistry, 2017
- N-Pyrenylmethoxycarbonyl phototriggers for the release of serotonin, tryptamine and their biosynthetic precursors
Fernandes, M.J.G.; Gon?alves, M.S.T.; Costa, S.P.G.
Dyes and Pigments, 2018
- Photolytic release of bioactive carboxylic acids from fused pyran conjugates
Concei?\~ao, R.; Hungerford, G.; Costa, S.P.G.; Gon?alves, M.S.T.
Dyes and Pigments, 2018
- Interaction of fluorescent quinolin-2-one and coumarin derivatives including dipeptides with lipid bilayers
Abreu, A.S.; Hermenegildo, B.F.C.; Ferreira, P.M.T.; Queiroz, M.J.R&period
RSC Advances, 2016
- Toxicity and structure-activity relationship (SAR) of α,β-dehydroamino acids against human cancer cell lines
Videira, R.A.; Andrade, P.B.; Monteiro, L.S.; Valent\~ao, P.; Ferreira, P&perio
Toxicology in Vitro, 2018
- Self-assembled RGD dehydropeptide hydrogels for drug delivery applications
Vila?a, H.; Castro, T.; Costa, F.M.G.; Melle-Franco, M.; Hilliou, L.; Ham
Journal of Materials Chemistry B, 2017
- Dextrin-Based Nanomagnetogel: In Vivo Biodistribution and Stability
Goncalves, C.; Silva, J. P.; Antunes, I. F.; Ferreira, M. F. M.; Martins, J&a
Bioconjugate Chemistry, 2015
- Partitioning of bovine lactoferrin in aqueous two-phase system containing poly(ethylene glycol) and sodium citrate
Costa, A.R.D.; Coimbra, J.S.D.R.; Ferreira, L.A.; Marcos, J.C.&
Food and Bioproducts Processing, 2015
- Curcumin Encapsulated into Methoxy Poly(Ethylene Glycol) Poly(epsilon-Caprolactone) Nanoparticles Increases Cellular Uptake and Neuroprotective Effect in Glioma Cells.
Marslin, Gregory; Sarmento, Bruno Filipe Carmelino Cardoso; Franklin, Gregory; Martins, Jose Alberto Ribeiro; Silva, Carlos Jorge Ribeiro; Gomes,
Planta medica, 2017
- Gold nanoparticles functionalised with fast water exchanging Gd<sup>3+</sup>chelates: Linker effects on the relaxivity
Ferreira, M.F.; Gon?alves, J.; Mousavi, B.; Prata, M.I.M.; Rodrigues, S&period
Dalton Transactions, 2015
- Photoactivation of Butyric Acid from 6-Aminobenzocoumarin Cages
Soares, A.M.S.; Hungerford, G.; Costa, S.P.G.; Gonçalves, M.S.T.
European Journal of Organic Chemistry, 2015
- Non-canonical amino acids bearing thiophene and bithiophene: synthesis by an Ugi multicomponent reaction and studies on ion recognition ability
Esteves, C.I.C.; Raposo, M.M.M.; Costa, S.P.G.
Amino Acids, 2017
- New fluoroionophores for metal cations based on benzo[d]oxazol-5-yl-alanine bearing pyrrole and imidazole
Esteves, C.I.C.; Ferreira, R.C.M.; Raposo, M.M.M.; Costa, S.P.G&
Dyes and Pigments, 2018
- PEGylated DOTA-AHA-Based Gd<sup>III</sup>Chelates: A Relaxometric Study
Fontes, A.; Karimi, S.; Helm, L.; Ferreira, P.M.; Andr\'e, J.P.
European Journal of Inorganic Chemistry, 2015
- Photoactivatable prodrugs of butyric acid based on new coumarin fused oxazole heterocycles
Soares, A.M.S.; Hungerford, G.; Costa, S.P.G.; Gon?alves, M.S.T.
Dyes and Pigments, 2017
- Ga[NO2A-N-(α-amino)propionate] chelates: Synthesis and evaluation as potential tracers for<sup>68</sup>Ga PET
Ferreira, M.F.; Pereira, G.; Andr\'e, J.P.; Prata, M.I.M.; Ferreira,
Journal of the Chemical Society. Dalton Transactions, 2014
- Novel functionalised imidazo-benzocrown ethers bearing a thiophene spacer as fluorimetric chemosensors for metal ion detection
Esteves, C.I.C.; Batista, R.M.F.; Raposo, M.M.M.; Costa, S.P.G&
Dyes and Pigments, 2016
- Fluorescent phenanthroimidazoles functionalized with heterocyclic spacers: Synthesis, optical chemosensory ability and two-photon absorption (TPA) properties
Ferreira, R.C.M.; Costa, S.P.G.; Gon?alves, H.; Belsley, M.; Raposo, M&
New Journal of Chemistry, 2017
- New cyclic RGD peptides: Synthesis, characterization, and theoretical activity towards α<inf>v</inf>β<inf>3</inf>integrin
Vilac?a, H.; Ferreira, P.M.T.; Micaelo, N.M.
Tetrahedron, 2014
- Dinuclear DOTA-based Gd<sup>III</sup> chelates - Revisiting a straightforward strategy for relaxivity improvement
Fontes, A.; Karimi, S.; Helm, L.; Yulikov, M.; Ferreira, P.M.; Andr\'e,
European Journal of Inorganic Chemistry, 2015
- Photolabile protection for amino acids: Studies on the release from novel benzoquinolone cages
Fonseca, A.S.C.; Soares, A.M.S.; Gon?alves, M.S.T.; Costa, S.P&p
Amino Acids, 2015
