The Applied Biomolecular Chemistry (ABC) research group is involved in a variety of projects that are linked by the use of biomolecules as targets or as tools for novel applications. The members of this group have different scientific backgrounds but all have a common foundation in the domain of Chemistry that permits them to contribute to interdisciplinary projects. These projects are carried out in collaboration with partners from other research centres, in Portugal and abroad.
The research interests of ABC group are:
- Development of new methods and new intermediates for peptide synthesis and their application in the production of peptides, peptide analogues and peptidomimetics
- Preparation of metal complexes for medical imaging.
- Development of new supramolecular hydrogels based on low molecular weight peptides
- Preparation and purification of biomolecules for therapeutic applications.
Paula Margarida Ferreira
- ABC Group Leader: Paula Margarida Ferreira
Recent ABC Publications:
- Dehydrodipeptide Hydrogelators Containing Naproxen N-Capped Tryptophan: Self-Assembly, Hydrogel Characterization, and Evaluation as Potential Drug Nanocarriers
Vila?a, H.; Hortel\~ao, A.C.L.; Castanheira, E.M.S.; Queiroz, M.-J.R&a
Biomacromolecules, 2015
- New cyclic RGD peptides: Synthesis, characterization, and theoretical activity towards α<inf>v</inf>β<inf>3</inf>integrin
Vilac?a, H.; Ferreira, P.M.T.; Micaelo, N.M.
Tetrahedron, 2014
- Partitioning of bovine lactoferrin in aqueous two-phase system containing poly(ethylene glycol) and sodium citrate
Costa, A.R.D.; Coimbra, J.S.D.R.; Ferreira, L.A.; Marcos, J.C.&
Food and Bioproducts Processing, 2015
- Gold nanoparticles functionalised with fast water exchanging Gd3+ chelates: linker effects on the relaxivity
Ferreira, Miguel F.; Goncalves, Janaina; Mousavi, Bibimaryam; Prata, Maria I. M.; Rodrigues, Sergio P. J.&
Dalton Transactions, 2015
- Synthesis and preliminary biological evaluation of new phenolic and catecholic dehydroamino acid derivatives
Monteiro, L.S.; Oliveira, S.; Paiva-Martins, F.; Ferreira, P.M.T.; Pereira, D.M&a
Tetrahedron, 2017
- New fluoroionophores for metal cations based on benzo[d]oxazol-5-yl-alanine bearing pyrrole and imidazole
Esteves, C.I.C.; Ferreira, R.C.M.; Raposo, M.M.M.; Costa, S.P.G&
Dyes and Pigments, 2018
- Photolabile protection for amino acids: Studies on the release from novel benzoquinolone cages
Fonseca, A.S.C.; Soares, A.M.S.; Gon?alves, M.S.T.; Costa, S.P&p
Amino Acids, 2015
- Non-canonical amino acids bearing thiophene and bithiophene: synthesis by an Ugi multicomponent reaction and studies on ion recognition ability
Esteves, C.I.C.; Raposo, M.M.M.; Costa, S.P.G.
Amino Acids, 2017
- Synthesis and evaluation of the chromo-fluorogenic recognition ability of imidazoquinoline derivatives toward ions
Mar\'in-Hern\'andez, C.; Santos-Figueroa, L.E.; El Sayed, S.; Pardo, T.; Raposo, M&p
Dyes and Pigments, 2015
- Photolytic release of bioactive carboxylic acids from fused pyran conjugates
Concei?\~ao, R.; Hungerford, G.; Costa, S.P.G.; Gon?alves, M.S.T.
Dyes and Pigments, 2018
- Dextrin-Based Nanomagnetogel: In Vivo Biodistribution and Stability
Goncalves, C.; Silva, J. P.; Antunes, I. F.; Ferreira, M. F. M.; Martins, J&a
Bioconjugate Chemistry, 2015
- Ga[NO2A-N-(α-amino)propionate] chelates: Synthesis and evaluation as potential tracers for<sup>68</sup>Ga PET
Ferreira, M.F.; Pereira, G.; Andr\'e, J.P.; Prata, M.I.M.; Ferreira,
Journal of the Chemical Society. Dalton Transactions, 2014
- Toxicity and structure-activity relationship (SAR) of α,β-dehydroamino acids against human cancer cell lines
Videira, R.A.; Andrade, P.B.; Monteiro, L.S.; Valent\~ao, P.; Ferreira, P&perio
Toxicology in Vitro, 2018
- Aminobenzocoumarinylmethyl esters as photoactive precursors for the release of butyric acid
Soares, A.M.S.; Hungerford, G.; Costa, S.P.G.; Gonçalves, M.S.T.
New Journal of Chemistry, 2015
- Synthesis of N-alkyl-C<sup>α,α</sup>-dimethylglycine derivatives
Monteiro, L.S.; Pereira-Lima, S.M.M.A.; Pereira, S.; Machado, J.N.
Arkivoc, 2014
- Gold nanoparticles functionalised with fast water exchanging Gd<sup>3+</sup>chelates: Linker effects on the relaxivity
Ferreira, M.F.; Gon?alves, J.; Mousavi, B.; Prata, M.I.M.; Rodrigues, S&period
Dalton Transactions, 2015
- Photoactivatable prodrugs of butyric acid based on new coumarin fused oxazole heterocycles
Soares, A.M.S.; Hungerford, G.; Costa, S.P.G.; Gon?alves, M.S.T.
Dyes and Pigments, 2017
- Dehydrodipeptide Hydrogelators Containing Naproxen N-Capped Tryptophan: Self-Assembly, Hydrogel Characterization, and Evaluation as Potential Drug Nanocarriers
Vilaca, Helena; Hortelao, Ana C. L.; Castanheira, Elisabete M. S.; Queiroz, Maria-Joao R. P.; Hilliou&com
Biomacromolecules, 2015
- Photolabile protection for amino acids: studies on the release from novel benzoquinolone cages
Fonseca, A.S.C.; Soares, A.M.S.; Gonçalves, M.S.T.; Costa, S.P&
Amino Acids, 2015
- Peptaibolin analogues by incorporation of α,α-dialkylglycines: Synthesis and study of their membrane permeating ability
Castro, V.I.B.; Carvalho, C.M.; Fernandes, R.D.V.; Pereira-Lima, S.M.M&per
Tetrahedron, 2016
- Interaction of fluorescent quinolin-2-one and coumarin derivatives including dipeptides with lipid bilayers
Abreu, A.S.; Hermenegildo, B.F.C.; Ferreira, P.M.T.; Queiroz, M.J.R&period
RSC Advances, 2016
- PEGylated DOTA-AHA-Based Gd<sup>III</sup>Chelates: A Relaxometric Study
Fontes, A.; Karimi, S.; Helm, L.; Ferreira, P.M.; Andr\'e, J.P.
European Journal of Inorganic Chemistry, 2015
- Fluorescent phenanthroimidazoles functionalized with heterocyclic spacers: Synthesis, optical chemosensory ability and two-photon absorption (TPA) properties
Ferreira, R.C.M.; Costa, S.P.G.; Gon?alves, H.; Belsley, M.; Raposo, M&
New Journal of Chemistry, 2017
- Photoactivable heterocyclic cages in a comparative release study of butyric acid as a model drug
Piloto, A.M.; Hungerford, G.; Sutter, J.U.; Soares, A.M.S.; Costa, S.P
Journal of Photochemistry and Photobiology A: Chemistry, 2015
- Novel functionalised imidazo-benzocrown ethers bearing a thiophene spacer as fluorimetric chemosensors for metal ion detection
Esteves, C.I.C.; Batista, R.M.F.; Raposo, M.M.M.; Costa, S.P.G&
Dyes and Pigments, 2016
- Light triggering of 5-aminolevulinic acid from fused coumarin ester cages
Soares, A.M.S.; Hungerford, G.; Gon?alves, M.S.T.; Costa, S.P.G.
New Journal of Chemistry, 2017
- New 2,4,5-triarylimidazoles based on a phenylalanine core: synthesis, photophysical characterization and evaluation as fluorimetric chemosensors for ion recognition
Esteves, C.I.C.; Raposo, M.M.M.; Costa, S.P.G.
Dyes and Pigments, 2016
- Dinuclear DOTA-based Gd<sup>III</sup> chelates - Revisiting a straightforward strategy for relaxivity improvement
Fontes, A.; Karimi, S.; Helm, L.; Yulikov, M.; Ferreira, P.M.; Andr\'e,
European Journal of Inorganic Chemistry, 2015
- Interactions between an Aryl Thioacetate-Functionalized Zn(II) Porphyrin and Graphene Oxide
Mao, Boyang; Calatayud, David G.; Mirabello, Vincenzo; Hodges, Benjamin J.; Ribeiro Martins, Jose Alberto; Botchway, Stanle
Advanced Functional Materials, 2016
- New self-assembled supramolecular hydrogels based on dehydropeptides
Vila?a, H.; Pereira, G.; Castro, T.G.; Hermenegildo, B.F.; Shi, J.; Faria
Journal of Materials Chemistry B, 2015
